GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs448396 | chr20:25440269 | FAM182B | chr20:25744102-25848786:- | 0.26 | 5.33 | 1.52E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs448396 | chr20:25440269 | NINL | chr20:25433338-25566153:- | -0.35 | -7.19 | 2.46E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs448396 | chr20:25440269 | PYGB | chr20:25228706-25278647:+ | -0.15 | -3.67 | 0.000272 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs438034 | 1 | rs448617 | chr1:214831287 | KCNK2 | chr1:215178885-215410435:+ | 0.17 | 3.46 | 0.000597 | Response to antineoplastic agents |
| THCA | cis | rs4534636 | 1 | rs4486677 | chr12:8669116 | CLEC4D | chr12:8666136-8674958:+ | 0.22 | 3.99 | 7.54E-5 | Response to radiotherapy in prostate cancer (toxicity, urinary frequency) |
| THCA | cis | rs13191362 | 1 | rs4489133 | chr6:163137793 | PACRG | chr6:163148164-163736523:+ | 0.54 | 7.47 | 3.95E-13 | Body mass index |
| THCA | cis | rs9876781 | 1 | rs4490383 | chr3:48484683 | ATRIP | chr3:48488141-48507708:+ | 0.19 | 4.22 | 2.93E-5 | Longevity |
| THCA | cis | rs9876781 | 1 | rs4490383 | chr3:48484683 | TREX1 | chr3:48501186-48509043:+ | -0.25 | -5.72 | 1.88E-8 | Longevity |
| THCA | cis | rs441810 | 1 | rs449043 | chr21:42700410 | FAM3B | chr21:42676177-42729654:+ | -0.53 | -7.9 | 1.88E-14 | Elevated serum carcinoembryonic antigen levels;Tumor biomarkers |
| THCA | cis | rs9475752 | 1 | rs4490669 | chr6:56789465 | BEND6 | chr6:56819773-56892138:+ | -0.28 | -6.1 | 2.26E-9 | Menarche (age at onset) |
| THCA | cis | rs9475752 | 1 | rs4490669 | chr6:56789465 | KIAA1586 | chr6:56911384-56920021:+ | -0.32 | -5.26 | 2.14E-7 | Menarche (age at onset) |
| THCA | cis | rs6805251 | 1 | rs4491945 | chr3:119598725 | GSK3B | chr3:119540804-119813264:- | -0.14 | -4.93 | 1.11E-6 | HDL cholesterol |
| THCA | cis | rs7107174 | 1 | rs4492844 | chr11:78026516 | NARS2 | chr11:78147017-78285909:- | -0.35 | -6.07 | 2.61E-9 | Testicular germ cell tumor |
| THCA | cis | rs449303 | 1 | rs449303 | chr14:60605788 | DHRS7 | chr14:60611502-60636561:- | -0.51 | -10.77 | 2.26E-24 | Age-related hearing impairment (interaction) |
| THCA | cis | rs4862307 | 1 | rs4493587 | chr4:185000525 | ENPP6 | chr4:185009860-185139114:- | -0.17 | -3.38 | 0.000798 | Serum dimethylarginine levels (asymmetric/symetric ratio) |